Korean Journal of Nephrology 2011;30(6):682-685.
Drug-induced Skin Hyperpigmentation after Usual Dosage of Bismuth-Containing Compound Medication in a Kidney Transplant Patient
Woosuk Choi, M.D., Hanul Choi, M.D., Ji Yong Jung, M.D., Jae Hyun Chang, M.D., Wookyung Chung, M.D., Hyun Hee Lee, M.D.
Division of Nephrology, Department of Internal Medicine, Gil Medical Center, Gachon University of Medicine and Science, Korea
증례 : 신장 이식 환자에서 통상적인 용량의 비스무트 포함 약제 복용 후 발생한 피부 과다색소침착 1예
최우석, 최하늘, 정지용, 장제현, 정우경, 이현희
가천의과학대학교 길병원 내과학교실 신장내과
Abstract
A 59-year-old male presented with multiple hyperpigmented skin with hyperkeratotic scaly patches on hands, feet and face. Bismuth containing compound had been prescribed two months before then due to epigastric pain, an adverse effect of steroid pulse therapy for acute rejection of transplanted kidney. Laboratory findings showed acute kidney injury and elevated liver enzyme. He stopped taking bismuth containing compound and all symptoms were gone after two months. Although there is no report on interaction between bismuth and immunosuppressant, it requires precaution to prescribe bismuth containing compounds in transplanted patients with acute kidney injury.
Key Words: Bismuth, Hyperpigmentation, Kidney transplantation


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